Home Ketamine Treatment for Depression in Seattle
Nomad Therapeutics
Medically supervised ketamine therapy for depression in Seattle—at home or in a therapist’s office. Evidence-informed care, screening, and monitoring.
13%
of US adults experienced depression
1 in 3
do not respond to first- line treatment
Depression isn’t one-size-fits-all. Many people improve with therapy, lifestyle changes, and antidepressant medications. But a meaningful subset continue to struggle despite multiple attempts—often described clinically as treatment-resistant depression (TRD).
Ketamine is increasingly used in medically supervised settings because it appears to work through different brain pathways than traditional antidepressants. For some patients, benefits can emerge on a faster timeline than conventional medications, which often take weeks to fully take effect.
Why ketamine is being used for hard-to-treat depression
How ketamine works differently
Most antidepressants primarily affect serotonin, norepinephrine, or dopamine. Ketamine works differently—primarily through the brain’s glutamate system (including NMDA receptors). This matters because glutamate plays a major role in learning, mood regulation, and the brain’s ability to form new connections.
Research suggests ketamine may:
Support neuroplasticity (the brain’s ability to adapt and form new pathways)
Reduce the intensity of depressive “loops” such as rumination and cognitive rigidity
Shift activity in brain networks involved in mood and self-referential thinking
For some patients, symptom change may begin on a faster timeline than standard antidepressants (which often require weeks). Response varies, and the best way to evaluate benefit is through structured treatment and outcome tracking.
Potential benefits of ketamine therapy for depression
In a 2023 randomized trial in treatment-resistant depression, 55.4% of patients in the ketamine group had a clinical response.
Patients pursuing ketamine therapy for depression often hope for:
Reduced depressive symptoms that have persisted despite other treatments
Improved emotional flexibility and a “less stuck” mental state
Greater capacity to engage in therapy and behavior change
In some clinical contexts, reductions in suicidal ideation have been observed
It’s important to set realistic expectations: ketamine is not a guarantee and not a cure. Our focus is responsible care—clear eligibility criteria, informed consent, monitoring, and ongoing assessment.
How Ketamine Treats Depression
Learn about the science and the impact from Yale Medicine
